RESUMO
It was established that the preparation form of pyrethroid during peroral, percutaneous uses is significantly more toxic than its components. The solvent in the composition of the preparative form increases the irritative properties of deltametatrin and also essentially effect mean time of death of half of the animals. Other toxicokinetic effects are discussed in detail.
Assuntos
Excipientes/toxicidade , Inseticidas/toxicidade , Piretrinas/toxicidade , Solventes/toxicidade , Animais , Sinergismo Farmacológico , Inseticidas/sangue , Dose Letal Mediana , Masculino , Nitrilas , Piretrinas/sangue , Ratos , Absorção Cutânea/efeitos dos fármacos , Fatores de TempoRESUMO
The main principles in the prevention of pesticide health hazards are a comprehensive toxicological evaluation of new compounds to be introduced into practice and adequate hygienic regulations allowing for all sorts of pesticides' pathogenic action and various sources of their supply from the environment. In acute, subacute and chronic experiments pesticides are examined for toxicity, adverse effects on reproductive function and embryogenesis, mutagenic, carcinogenic and allergenic potential. The hygienic classification is based on the limiting criterion of the greatest damage. Safe levels are derived from the tolerance thresholds resting on persistence and changes of the shifts found, from investigations of borderline health conditions, assessment of homeostasis, hepatic immune and monooxygenase systems involved in metabolism of lipid-soluble pesticides. Animal experiments findings extrapolated to clinical conditions help to predict probable long-term responses. The directions of the research into prevention of pesticides-induced health hazards are outlined.
Assuntos
Praguicidas/efeitos adversos , Animais , Humanos , Praguicidas/normas , Praguicidas/toxicidade , U.R.S.S.RESUMO
It was shown on a model of intoxication of hens with aphos possessing a selective neuroparalytic action that the target-enzyme neurotoxic esterase changed its activity in the brain, spleen and lymphocytes of the peripheral blood. The authors describe a method of determination of the activity of neurotoxic esterase in human peripheral blood lymphocytes that may be used for biomonitoring of the effect of phosphorus organic compounds possessing a delayed neurotoxic action.
Assuntos
Hidrolases de Éster Carboxílico/sangue , Inseticidas/toxicidade , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/enzimologia , Hidrolases de Éster Carboxílico/antagonistas & inibidores , Galinhas , Feminino , Humanos , Linfócitos/efeitos dos fármacos , Linfócitos/enzimologia , Compostos Organofosforados/toxicidade , Baço/efeitos dos fármacos , Baço/enzimologiaAssuntos
Ataxia/induzido quimicamente , Encéfalo/efeitos dos fármacos , Hidrolases de Éster Carboxílico/antagonistas & inibidores , Inseticidas/efeitos adversos , Compostos Organofosforados , Paralisia/induzido quimicamente , Animais , Encéfalo/enzimologia , Hidrolases de Éster Carboxílico/metabolismo , Galinhas , Feminino , Cobaias , Ratos , Fatores de TempoAssuntos
Inseticidas/farmacocinética , Compostos Organofosforados , Animais , Inibidores da Colinesterase , Inseticidas/intoxicação , Inseticidas/toxicidade , Dose Letal Mediana , Compostos Organotiofosforados , Ratos , Relação Estrutura-Atividade , Fatores de Tempo , Distribuição Tecidual/efeitos dos fármacosRESUMO
Zyxorin (50-100 mg/kg) was found to produce a significant increase of the content (activity) of components of electron transport microsomal circuit and is similar to phenobarbital by its inducing effect. At preventive and therapeutic-preventive administration it enhances resistance of albino rats to anticholinesterase pesticides (actellis, valexon, 0,0-dimethyl-0-2,2-dichlorvinylphosphate, clorofos, hostaquick, dioxycarb, primor, sevine, furadan), prevents the development of neuromuscular blockade. The introduction of zyxorin into a complex therapy with specific agents (atropine, reactivators of cholinesterase) potentiates their antidotic effect at poisoning with DDVP.
Assuntos
Carbamatos , Inibidores da Colinesterase/intoxicação , Inseticidas/intoxicação , Compostos Organofosforados , Animais , Antídotos/uso terapêutico , Atropina/uso terapêutico , Reativadores da Colinesterase/uso terapêutico , Sinergismo Farmacológico , Fígado/enzimologia , Microssomos Hepáticos/enzimologia , RatosRESUMO
The inhibition of neurotoxic esterase activity in chicken brain has been studied in vitro and in vivo. Aphos exposure, causing chicken paralysis, has demonstrated that the initial stage of delayed neurotoxicity was significant esterase activity inhibition (by 60-80%) within 3-24 hours after the pesticide administration. The inhibition of cholinesterase activity occurred both in the blood and sciatic nerve. The delayed conduction through peripheral nerves caused by demyelination has been revealed in the latent period (before the clinical signs of intoxication).
Assuntos
Inseticidas/toxicidade , Compostos Organofosforados , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Animais , Hidrolases de Éster Carboxílico/antagonistas & inibidores , Galinhas , Inibidores da Colinesterase , Dose Letal Mediana , Condução Nervosa/efeitos dos fármacos , Doenças do Sistema Nervoso Periférico/fisiopatologia , Fatores de TempoAssuntos
Piretrinas/toxicidade , Animais , Colinesterases/metabolismo , Eritrócitos/efeitos dos fármacos , Eritrócitos/enzimologia , Humanos , Técnicas In Vitro , Inseticidas/toxicidade , Dose Letal Mediana , Fígado/efeitos dos fármacos , Fígado/enzimologia , Camundongos , Compostos Organofosforados , Oxirredutases/metabolismo , Ratos , Fatores de TempoRESUMO
It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.
Assuntos
Fungicidas Industriais/toxicidade , Compostos Organofosforados/toxicidade , Nervos Periféricos/efeitos dos fármacos , Potenciais de Ação/efeitos dos fármacos , Animais , Galinhas , Relação Dose-Resposta a Droga , Contaminação de Medicamentos , Emulsões , Feminino , Fungicidas Industriais/intoxicação , Junção Neuromuscular/efeitos dos fármacos , Junção Neuromuscular/fisiologia , Intoxicação por Organofosfatos , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Transmissão Sináptica/efeitos dos fármacos , Fatores de TempoRESUMO
Electron paramagnetic resonance was used to study over time metal proteins (cytochrome P-450, cytochrome-c-oxidase, iron and sulfur proteins) and free radicals in rat liver under acute (LD50) oral intoxication with 2,4-dinitro-6-butylphenol and 2,4-dinitro-6-methylphenol used as pesticides. The authors describe the kinetics of variations in the content of metal proteins and free radicals under the effect of the above-indicated toxic agents. It is assumed that the triggering mechanism of the toxic action of dinitrophenols lies in the inhibition of the function of iron and sulfur proteins. Possible mechanisms of the disturbance of the energy and detoxifying systems of the body under experimental conditions described are reviewed.